Solentim’s unrivalled All-in-One VIPS™ and VIPS PRO™ systems uniquely combine single cell seeding and whole well imaging, providing up-front assurance of clonality, saving time and money
The Solentim VIPS™ and VIPS PRO™ systems take single cell cloning and image based clonality assurance to a whole new level of quality. Theses multi-tasking, compact instruments deliver a rock solid, ‘double lock’ solution for regulatory submission. With the VIPS seeders, two-round methodologies are a thing of the past.
Elevating single cell seeding workflows
VIPS seeders accelerate projects. With VIPS seeders you get healthier cells, more confirmed single cells per plate and better outgrowth. High seeding efficiency for both 96 and 384-well plates, single round workflows for massively enhanced productivity and reduced timelines.
Delivering proof of monoclonality, not probability
With VIPS seeders, clonal assurance is based on evidence, unlike manual methods which use a repeated process to achieve probability of a single cell. VIPS seeders deliver evidence at multiple steps for complete certainty of single cell seeding — not in the nozzle, not in the tube, not in the air, but at the bottom of the well.
Highest assurance of clonality
Designed specifically for the task, Solentim technology is honed for single cell imaging in the droplet by way of z-stack imaging and in the whole well. With high clarity images, even when near the cell wall, VIPS seeders generate confidence for the lab and the regulator.
The Solentim ecosystem
Workflows for IND success
Assurance of clonality
Operating at a pressure of less than one psi, VIPS seeders gently dispense cells in nanoliter droplets into a plate well. Crucially, the cell is imaged in the bottom of the dry well as evidence of seeding. Automated imaging in multiple tight z-stack layers of the whole droplet commences with intelligence-based image analysis confirming the existence of a single cell. The well is then filled automatically with media.
During the clonal growth phase, VIPS seeders perform daily high-clarity whole well imaging, recording a timeline of well images and performing analysis to measure confluency. Successful clonal outgrowth can be traced back to a single cell to confirm monoclonality.
VIPS seeders perform total plate laser focus scanning, adjusting for plate contours, to ensure an optimal focal position for each well.
VIPS seeders perform total plate laser focus scanning, adjusting for plate contours, to ensure an optimal focal position for each well.
To assist in the verification of your clonality workflow, the VIPS and VIPS PRO offer a verification methodology option based on rare-event fluorescence imaging.
To assist in the verification of your clonality workflow, the VIPS and VIPS PRO offer a verification methodology option based on rare-event fluorescence imaging.
VIPS System
VIPS combines high efficiency seeding, in-well verification and high contrast whole well imaging to provide up-front assurance of clonality.
VIPS System
VIPS PRO System
VIPS PRO’s powerful seeding technology gently and efficiently dispenses cells, reducing hands-on time and compresses timelines from months to days. Now with solutions to support GMP-certification, VIPS PRO provides certainty of clonality through superior imaging, advanced data management and single-use GMP-compliant consumables.
VIPS PRO System
The Solentim ecosystem
Workflows for IND success
Assurance of clonality
The Solentim VIPS seeders accelerate single cell cloning workflows while also ensuring clonality to drive the discovery and development of antibody, cell & gene therapies and iPSC-based studies.
High efficiency, high viability single cell cloning of hiPSCs for applications including development of disease models and supporting GMP manufacture of cell therapies
Generate stable cell lines that create producing novel recombinant proteins such as monoclonal antibodies or therapeutic proteins for rare diseases
From the selection of high producer clones to the development of stable vector producer cell lines, explore our simplified workflows for gene therapy applications
Generate stable cell lines that create producing novel recombinant proteins such as monoclonal antibodies or therapeutic proteins for rare diseases
Isolate, screen and characterise attributes for clones producing novel recombinant sub-unit protein and monoclonal antibody vaccines
Establish stable producer cells for the production of engineered and cell-engineered exosomes
Optimise your drug discovery process using targeted gene editing to create stable cell lines as cellular reagents, for use in target validation, functional genomics and disease modelling
Isolate, screen and characterise attributes for clones producing novel recombinant sub-unit protein and monoclonal antibody vaccines
