The smartest decision-making platform in cell line development
Rank best producers quicker, without risk of error
Track clones from seeding to selection
Easy regulatory compliance
HISTORYTREE™ graphically represents a cell’s journey through cell line development, independent of sample formats. From seeding, through growth, productivity assays, ranking and selection, coloured nodes represent time points in the cell’s journey offering easy access to critical data and an audit trail.
ICON System
STUDIUS Data Management Platform
Enhanced CLD workflows for IND success
The Solentim Ecosystem
The ICON with STUDIUS can uniquely measure both titre and viable cell density in the same instrument. Automatic ranking of best producers is performed easily according to user defined parameters.
Combine VIPS seeding and Cell Metric clonality data with ICON titre measurements in order to automatically select your best performing clones and avoid laborious comparison of results files.
20 – 60 μL samples enable measurements much earlier in your fed-batch process for faster and more confident decision-making.
Samples are tracked across your workflow from the cloning plate, through fed-batch suspension shaking cultures to shake flask and multi-parallel mini bio-reactors such as AMBR. For automated liquid handlers, STUDIUS communicates source and destination locations to the robot ensuring consistent sample tracking.
In the STUDIUS ecosystem, raw data results from all Solentim instruments go directly and securely without external manipulation into a single common database for ultimate data integrity.
Titre is measured using fluorescence polarisation and needs only 60 μL per assay. This means that titre can be measured earlier in the process, for example in Day 14 static cloning plates or 48 /24 deep-well suspension shaking plates. Earlier titre measurements allow earlier stratification of high producing clones.
Viable cell density is measured using Trypan blue exclusion. Cultures up to 107 cells/mL can be counted and the count is qualified with a supporting high resolution image showing the denotation of live versus dead cells. The assay requires only 20 μL of sample, much less than incumbent cell viability analysers requiring several hundreds of microlitres.
STUDIUS provides consistency across the cell line development workflow via secure sample/clone tracking through a common database, eliminating cumbersome and error prone comparison of results in various formats from multiple suppliers instrumentation.
The current paradigm in cell line development involves comparison and cross referencing of excel spreadsheets containing for example, clonal outgrowth and productivity results. This tedious process increases the risk of error and reduces confidence in the overall clone selection process. STUDIUS manages results from Solentim’s cell line development instrument portfolio, thus eliminating time consuming and error-prone visual comparison of data in different formats.
The ICON with integrated STUDIUS data management platform enables scientists in the biotherapeutic development industry to digitally transform their process and make informed decisions quicker, earlier, and more securely.
ICON System
The STUDIUS powered ecosystem provides a more consistent cell line development workflow for scientists creating biotherapeutic Master Cell Banks, enabling faster and more confident decision making.
STUDIUS Data Management Platform
