Bionex Solutions
Nanodrop Systems
High-throughput, low-volume dispensing
Nanodrop II (8-channel) and Nanodrop Express (16-channel)
Next-generation label-free analysis
BLI is a powerful technology that is flexible, highly-sensitive and accessible. From experiment to analysis, characterise the widest range of molecules on a single easy-to-use platform ― in a single run.
True low volume, high throughput subvisible particle analysis
Aura systems help you develop stable, pure, and efficacious protein, cell, and gene therapies faster. By combining the sensitivity of BMI with fluorescent detection, Aura systems enable high-throughput particle count, size and identification.
Next-generation label-free analysis
BLI is a powerful technology that is flexible, highly-sensitive and accessible. From experiment to analysis, characterise the widest range of molecules on a single easy-to-use platform ― in a single run.
True low volume, high throughput subvisible particle analysis
Aura systems help you develop stable, pure, and efficacious protein, cell, and gene therapies faster. By combining the sensitivity of BMI with fluorescent detection, Aura systems enable high-throughput particle count, size and identification.
Nanodrop II (8-channel) and Nanodrop Express (16-channel)
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Each system has interchangeable, fixed-tip heads (1 × 8 or 2 × 4 configurations for the Nanodrop II and 1 × 16 or 2 × 8 configurations for the Nanodrop Express) and comes with two plate positions that enable applications such as assay miniaturisation, DNA normalisation, method development, PCR and NGS reaction setup, or protein crystallography.
Fast, low volume, high-precision dispensing
Nanodrop technology aspirates and dispenses a broad range of liquids, including DMSO. Nanodrop systems contain micro solenoid valves for fast, precise low-volume applications and mixing.
Valve-free fluid path for outstanding reliability
This patented technology isolates the solenoid dispense actuators from the sample path to assure long life and easy, low-cost maintenance – even with regular use of difficult suspensions such as proteins, cells and YOx beads.
Easy to program and automate
Nanobuilder software system enables a wide range of applications and data manipulation.
Non-contact liquid handling relies on the combined use of rapidly actuated solenoid dispense valves, a controlled pressurised liquid source, and flow path control via hybrid valves. The speed and energy of the fluid displacement enables the surface tension of the liquid to break as it leaves the orifice, eliminating the need for a touch-off. The lack of a touch-off step in the dispense eliminates the variability issues associated with touching off.
An important added benefit of non-contact dispensing is speed — the non-contact technique allows the delivery nozzle to accurately deliver the droplet above the target well and rapidly move to the next well. With the non-contact technique dispensing becomes independent of the substrate, eliminating many of the reproducibility problems associated with motion control. Plate processing times fall dramatically. Using non-contact dispensing it is possible to deliver to all wells of a 96 well plate in approximately 5 sec, 384 wells in approximately 7 sec, and 1536 wells in approximately 14 sec.
Nanodrop systems pipette up to 8 or 16 reagents simultaneously, possessing broad versatility for dispensing and mixing applications. This technology has exceptional dynamic range (nL – mL) and is fast, low-volume and precise.
Nanodrop systems are capable of dispensing a different volume into every well. Interchangeable fixed-tip heads allow for flexible dispense configuration.
Non-contact dispensing allows for simple cleaning and maintenance. Additionally, FEP, SS and sapphire wetted parts are compatible with commonly used solvents.
8-channel high-throughput, low-volume dispensing system
16-channel ultra high-throughput, low-volume dispensing system
Nanodrop II and Nanodrop Express
Typical applications of the Nanodrop systems include:
Nanodrop II | Nanodrop Express | |
---|---|---|
Number of channels | 8 | 16 |
Dispense Time (1536-well plate, 1 µL dispense) | < 17 sec | < 8 sec |
Dispense Range: Microsolenoids 500 µL syringe 1000 µL syringe | 0.1 - 80 µL 5 - 500 µL 5 - 1000 µL | |
Aspirate Range: 500 µL syringe 1000 µL syringe | 0 - 500 µL 0 - 1000 µL | |
Dispense Precision | 100 nL ≤ 10% 200 nL ≤ 7% 1 µL ≤ 5% | |
Residual Volume | < 3 µL per channel |