SOLENTIM
VIPS PRO
VERIFIED IN-SITU PLATE SEEDING
Solentim’s unrivalled All-in-One VIPS PRO™ system uniquely combines single cell seeding and whole well imaging, providing up-front assurance of clonality, saving time and money
Next-generation label-free analysis
BLI is a powerful technology that is flexible, highly-sensitive and accessible. From experiment to analysis, characterise the widest range of molecules on a single easy-to-use platform ― in a single run.
True low volume, high throughput subvisible particle analysis
Aura systems help you develop stable, pure, and efficacious protein, cell, and gene therapies faster. By combining the sensitivity of BMI with fluorescent detection, Aura systems enable high-throughput particle count, size and identification.
Next-generation label-free analysis
BLI is a powerful technology that is flexible, highly-sensitive and accessible. From experiment to analysis, characterise the widest range of molecules on a single easy-to-use platform ― in a single run.
True low volume, high throughput subvisible particle analysis
Aura systems help you develop stable, pure, and efficacious protein, cell, and gene therapies faster. By combining the sensitivity of BMI with fluorescent detection, Aura systems enable high-throughput particle count, size and identification.
Solentim’s unrivalled All-in-One VIPS PRO™ system uniquely combines single cell seeding and whole well imaging, providing up-front assurance of clonality, saving time and money
The Solentim VIPS PRO™ system takes single cell cloning and image based clonality assurance to a whole new level of quality. This multi-tasking, compact instrument delivers a rock solid, ‘double lock’ solution for regulatory submission. With the VIPS PRO seeder, two-round methodologies are a thing of the past.
Elevating single cell seeding workflows
The VIPS PRO seeder accelerates projects. With VIPS PRO you get healthier cells, more confirmed single cells per plate and better outgrowth. High seeding efficiency for both 96 and 384-well plates, single round workflows for massively enhanced productivity and reduced timelines.
Delivering proof of monoclonality, not probability
With VIPS PRO, clonal assurance is based on evidence, unlike manual methods which use a repeated process to achieve probability of a single cell. VIPS PRO delivers evidence at multiple steps for complete certainty of single cell seeding — not in the nozzle, not in the tube, not in the air, but at the bottom of the well.
Highest assurance of clonality
Designed specifically for the task, Solentim technology is honed for single cell imaging in the droplet by way of z-stack imaging and in the whole well. With high clarity images, even when near the cell wall, VIPS PRO generates confidence for the lab and the regulator.
The Solentim ecosystem
Workflows for IND success
Assurance of clonality
Operating at a pressure of less than one psi, VIPS PRO gently dispenses cells in nanoliter droplets into a plate well. Crucially, the cell is imaged in the bottom of the dry well as evidence of seeding. Automated imaging in multiple tight z-stack layers of the whole droplet commences with intelligence-based image analysis confirming the existence of a single cell. The well is then filled automatically with media.
During the clonal growth phase, VIPS PRO performs daily high-clarity whole well imaging, recording a timeline of well images and performing analysis to measure confluency. Successful clonal outgrowth can be traced back to a single cell to confirm monoclonality.
Immediately after confirmation of cell seeding, VIPS PRO automatically dispenses culture media into the well, protecting your high-value cell.
VIPS PRO performs total plate laser focus scanning, adjusting for plate contours, to ensure an optimal focal position for each well.
VIPS seeders perform total plate laser focus scanning, adjusting for plate contours, to ensure an optimal focal position for each well.
To assist in the verification of your clonality workflow, the VIPS PRO offers a verification methodology option based on rare-event fluorescence imaging.
To assist in the verification of your clonality workflow, the VIPS and VIPS PRO offer a verification methodology option based on rare-event fluorescence imaging.
VIPS PRO
VIPS PRO’s powerful seeding technology gently and efficiently dispenses cells, reducing hands-on time and compresses timelines from months to days. Now with solutions to support GMP-certification, VIPS PRO provides certainty of clonality through superior imaging, advanced data management and single-use GMP-compliant consumables.
VIPS PRO System
The Solentim ecosystem
Workflows for IND success
Assurance of clonality
The Solentim VIPS PRO seeder accelerates single cell cloning workflows while also ensuring clonality to drive the discovery and development of antibody, cell & gene therapies and iPSC-based studies.
High efficiency, high viability single cell cloning of hiPSCs for applications including development of disease models and supporting GMP manufacture of cell therapies
Generate stable cell lines that create producing novel recombinant proteins such as monoclonal antibodies or therapeutic proteins for rare diseases
From the selection of high producer clones to the development of stable vector producer cell lines, explore our simplified workflows for gene therapy applications
Generate stable cell lines that create producing novel recombinant proteins such as monoclonal antibodies or therapeutic proteins for rare diseases
Isolate, screen and characterise attributes for clones producing novel recombinant sub-unit protein and monoclonal antibody vaccines
Establish stable producer cells for the production of engineered and cell-engineered exosomes
Optimise your drug discovery process using targeted gene editing to create stable cell lines as cellular reagents, for use in target validation, functional genomics and disease modelling
Isolate, screen and characterise attributes for clones producing novel recombinant sub-unit protein and monoclonal antibody vaccines