Solutions for the Medicinal Cannabis Industry
CANNABIS PURIFICATION
Simplify workflows with Gilson’s VERITY CPC Systems
The right choice for cannabinoid purification
IMPROVED CANNABINOID YIELD AND ZERO SAMPLE LOSS AT LESS COST
Gilson’s line of VERITY Centrifugal Partition Chromatography (CPC) instruments deliver high yielding, efficient and scalable extraction and purification solutions to the medicinal cannabis industry. Being a silica-free technology makes CPC very cost-effective, and it’s dramatically reduced solvent use results in a more environmentally-friendly, green extraction method.
High yield, reproducible, fast and scalable
Easy scale-up with fully integrated systems providing high yields, high purity, high speed and minimal product loss. Future proof your process with the flexibility for research, pilot and industrial scale production on a GMP compatible system.
An efficient, cost-effective green technology
CPC being a silica free technology means there is no need to replace columns or recycle silica. CPC’s capacity to recycle solvent saves you up to 80% on solvent use compared to solid-phase extraction methods.
Helping our customers achieve success
With over 40 years of experience in preparative and industrial chromatography, Gilson offers expertise and worldwide services to support you. From lab to industrial scale, Gilson have supported hundreds of cannabis scientists and technicians around the world with purification services and systems.
DOWNLOAD BROCHURES FOR MORE INFORMATION
Solutions for the Cannabis Industry
Introduction to CPC
Natural product purification systems
Solutions for the Cannabis Industry
Introduction to CPC
Cost-effective cannabinoid purification
VERITY CPC Process System
Natural Product Purification Systems
Technology
The technology behind CPC purification
Chromatographic purification of natural compounds presents many challenges to scientists because of the complex nature of the starting matrices that are used in the process. Rather uniquely, CPC uses both liquid stationary and mobile phases and as such can handle heavily contaminated, complex starting materials such as direct extracts from many biological sources.
Separation is based on liquid-liquid partitioning:
- Uses 2 immiscible liquid phases
- The stationary phase is contained by centrifugal force
- The mobile phase pumps through the stationary phase
- Compounds are separated through their relative affinity to each liquid phase
SYSTEMS
Cost effective and scalable solutions for obtaining
high purity cannabinoids from a crude extract
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VERITY CPC
purification systems
From lab to industrial scale, Gilson offers complete cannabinoid purification solutions
Services
Complete cannabinoid purification solutions provider
Gilson don’t just develop market leading technology. Their dedicated and experienced teams are available to make sure that you get the best from their systems with a range of purification services including engineering design, application development, feasibility and scale-up studies, qualification support, and installation services as part of operational ramp-up.
Solve Scientific as Gilson’s exclusive instruments representative, have local staff each with over 25 years’ experience working with Gilson. Together, with the backing of a global network of CPC Application Specialists, CPC Service & Validation Engineers, and factory support from Gilson’s CPC Centres of Excellence, Solve Scientific can uniquely provide Australian and NZ customers easily accessible local expertise with applications tailored to serve business strategies, and service and support to keep instruments running at peak performance.
From lab to industrial scale, Gilson has supported hundreds of cannabis scientists and technicians
around the world with their purification services and systems
| Your needs, our goal | Assess the potential of your sample | Perform Proof of Concept up to process scale | Optimise your own production resources |
|---|---|---|---|
| How we can support you | 1. Screen available feasibility studies | 4. Perform the intensification and scale-up studies | 7. Assist with the organisation of the production process |
| 2. Develop methods optimised for your sample | 5. Produce up to kilograms of pure molecules (as raw material or for trials) | 8. Train your teams at a Gilson Purification centre and/or on-site | |
| 3. Produce up to several grams of pure molecules (as a standard or for trials) | 6. Review the economics and risks related to large scale production | 9. Provide support and equipment through the operational ramp up stage |
Interested in learning more?
Whether you are at the beginning of your journey or already at production stage, contact us with any questions you might have or to learn more about Gilson cannabis purification products, systems, and services.
Solutions for the Cannabis Industry
Leverage global expertise with local service and support to accelerate your cannabis purification project outcomes
With over 40 years of experience in preparative and industrial chromatography, Gilson Purification services teams have worked hand-in-hand with cannabis researchers and businesses, bringing them:
Extensive command of the entire processing workflow and the main purification techniques applied with cannabis (prep HPLC, flash, and CPC)
Access to state-of-the-art databases and lab facilities built to address research, pilot, and process scale challenges
End-to-end services from feasibility study to production, including industrial intensification, operator training, and product value optimisation
Solve Scientific offering easily accessible local, reactive service and support that can be provided directly at your site or real-time via dedicated software and tools solutions.
Applications
Purification of Cannabidiol from Cannabis sativa
Cannabidiol (CBD) is a non-psychotropic cannabinoid from the Cannabis sativa L. (Cannabaceae) plant. Researchers have shown that CBD’s medicinal properties may be of use for treating a variety of conditions including pain, inflammation, epilepsy, and cancer. Changes in the legal status of cannabis for medical use, along with the increasing number of therapeutic applications for CBD, has resulted in rapidly growing demand for highly pure CBD. As such, it is crucial to develop standardised CBD products free of unwanted components to ensure patient safety. CBD manufacturers will require efficient, cost-effective methods that can produce high yields of impurity-free products.
This article describes a rapid and reproducible method for large-scale purification of pure CBD using CPC.
CPC purification of Cannabidiol
Single-step purification of cannabinoids by CPC
Single-step purification of THC, CBD, CBN, CBG and minor cannabinoids
CPC is recognised as the preferred technology for the purification of high quality Δ-9-tetrahydrocannabinol (THC) and cannabidiol (CBD) for the pharmaceutical and food supplement markets. The objective of this app note was to test the high selectivity of CPC and assess its capability to purify a set of key compounds (THC, CBD, CBN and CBG) and enrich several minor cannabinoids (CBDV, CBCV and CBC).
Multi-ton processing of full spectrum cannabis oil for THC remediation
Δ-9-tetrahydrocannabinol (THC) content in cannabis products, such as food supplements, vapes, or medicinal matrices, is strictly regulated in most countries worldwide. This has fuelled demand for broad spectrum THC-free oil, and spurred interest in THC remediation technologies applicable at industrial scale level. CPC is a preferred technology with natural product purification due to its ability to extract, remove or purify a target compound without denaturing or losing other compounds present with it in the sample.
This application note demonstrates the added value of CPC for THC remediation of multiple tons of full-spectrum oil.
Multi-ton processing of cannabis oil for remediation by CPC
DOWNLOAD BROCHURES FOR MORE INFORMATION
Solutions for the Cannabis Industry
Introduction to CPC
Natural product purification systems
VERITY CPC Process System